Occasionally, products with excellent water solubility are encountered in organic synthesis. The common ethyl acetate (addition of tetrahydrofuran) or dichloromethane (addition of methanol) cannot be used to extract the product. You can consider using acetonitrile(CAS: 75-05-8) to extract the product, but first let the original Water miscible acetonitrile and water layer. The following are a few situations in which acetonitrile and water can be separated. Add a large amount of inorganic salts to saturate the water phase, and then extract with acetonitrile(CAS: 75-05-8) . After testing, some carboxylic acids with excellent water solubility can be extracted. The method of adding sugar has not been tried. The low-temperature stratification is common in the freeze-drying preparation liquid. You can test it later to see if there is an extraction effect.
1 Salt and acetonitrile-water system
Occasionally, products with excellent water solubility are encountered in organic synthesis, and the products cannot be extracted by common ethyl acetate (addition of tetrahydrofuran) or dichloromethane (addition of methanol), and acetonitrile (CAS: 75-05-8) can be considered. ) to extract the product, but first by allowing the water-miscible acetonitrile to separate. The following are a few situations in which acetonitrile and water can be separated. Add a large amount of inorganic salts to saturate the water phase, and then extract with acetonitrile. After testing, some carboxylic acids with excellent water solubility can be extracted. The method of adding sugar has not been tried. The low-temperature stratification is common in the freeze-drying preparation liquid. You can test it later to see if there is an extraction effect.
2 Sugar and acetonitrile-water system
In 2008, Wang from the University of Illinois reported a phase separation phenomenon between acetonitrile and water induced by sugar. When more than a certain threshold of monosaccharides (glucose, xylose, arabinose or fructose) or disaccharides (sucrose or maltose) were added to the acetonitrile-water solution, a clear phase separation was seen. Polysaccharides do not possess such phase separation inducing properties. Other commonly used water-miscible organic solvents (eg methanol, ethanol, n-propanol, isopropanol, acetone) do not possess such sugar-induced phase separation from water. The upper phase after phase separation is an acetonitrile-rich phase, and the lower phase is an acetonitrile-poor phase. The extraction method based on this phenomenon is called acetonitrile saccharide extraction method.
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